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ey0020.9-13 | Obesity and Insulin/Glucose Metabolism | ESPEYB20

9.13. Lack of evidence for a causal role of hyperinsulinemia in the progression of obesity in children and adolescents: a longitudinal study

R Halloun , A Galderisi , S Caprio , R Weiss

Brief summary: This longitudinal study aimed to determine if hyperinsulinemia and postprandial glucose levels could predict obesity progression in n=591 children and adolescents with obesity. The authors found no association between hyperinsulinemia, insulin secretion, low postprandial glucose levels, and an increase in obesity over a 24-year period.According to the carbohydrate-insulin model (1), diets with a high glycemic load (GL) promote weight...

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ey0015.11-2 | New insight into obesity comorbidities | ESPEYB15

11.2 Impact of severe obesity on cardiovascular risk factors in youth

G Zabarsky , C Beek , E Hagman , B Pierpoint , S Caprio , R Weiss

To read the full abstract: Journal of Pediatrics 2018;192:105-114Rising degree of obesity has been shown to predict increased metabolic risk in obese children and adolescents (1). Nonetheless, it is unclear if BMI categories can be successfully applied to populations of obese children and adolescents for a risk-adapted stratification of therapeutic approaches, and here especially for the in...

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ey0015.12-3 | New Mechanism | ESPEYB15

12.3 The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing beta-Cell Function and Hepatic Insulin Sensitivity

C Cropano , N Santoro , L Groop , C Dalla Man , C Cobelli , A Galderisi , R Kursawe , B Pierpont , M Goffredo , S Caprio

To read the full abstract: Diabetes Care 2017;40:1082-1089Transcription factor 7-like 2 (TCF7L2) is a protein encoded by the TCF7L2 gene located on chromosome 10q25.2-q25.3 and is involved in the development of a wide variety of cell lineages and organs. The rs7903146 <a href="https://en.wikipedia.org...

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ey0020.10-6 | New Drugs for Children with T2DM | ESPEYB20

10.6. Deterioration of glycemic control in youth-onset type 2 diabetes: What are the early and late predictors?

P Zeitler , L El Ghormli , S Arslanian , S Caprio , E Isganaitis , MK Kelsey , RS Weinstock , NH White , K Drews

Brief summary: In this study of 699 youth 10 to < 18 years old with <2 years duration of type 2 diabetes (T2D) at 15 centers across the USA, baseline HbA1c level, and the change in HbA1c level in the first 6 months are predictors of rapid glycemic deterioration. In addition, subsequent loss of control can be predicted based on both baseline and ongoing clinical characteristics.Comment: The population of individuals with youth-onset T2D is heterog...

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ey0019.12-3 | New data on complications of children with T2DM | ESPEYB19

12.3. Long-term complications in youth-onset type 2 diabetes

P. TODAY Study Group, Bjornstad P, Drews KL, Caprio S, Gubitosi-Klug R, Nathan DM, Tesfaldet B, Tryggestad J, White NH, Zeitler

The New England Journal of Medicine 2021;385(5):416-26. doi: 10.1056/NEJMoa2100165Brief Summary: This multicenter observational study assessed the cumulative incidence of diabetic complications in 500 adolescents with Type 2 diabetes (T2DM), followed from 2011 to 2020. After only 13 years from T2DM diagnosis, higher complication rates were observed than those reported for pediatric patients wit...

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ESPE Yearbook of Paediatric Endocrinology

9.13. Lack of evidence for a causal role of hyperinsulinemia in the progression of obesity in children and adolescents: a longitudinal study

11.2 Impact of severe obesity on cardiovascular risk factors in youth

12.3 The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing beta-Cell Function and Hepatic Insulin Sensitivity

10.6. Deterioration of glycemic control in youth-onset type 2 diabetes: What are the early and late predictors?

12.3. Long-term complications in youth-onset type 2 diabetes

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